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Research


"Creating a new reaction and functional system"
Based on organic chemistry, we are developing a variety of research on new reactions, new materials, and new functions as keywords. In a new reaction development, we aim to create a molecular transformation fundamentally different from existing methods in the reaction mechanism and bond fromation. We are also constructing functional systems based on π-conjugated molecules and/or biomolecules.


Research
projects
· Tranformation of "strong bond" by transition-metal complex catalysts
· Novel reactions utilizing the unique reactivity of heteroatom-metal species
· Creation of functional π-conjugated molecules
· Design of conjugated redox system and its application to organic synthesis and functional materials
· Construction of bio-conjugate system

 

 

The following is the projects that we have worked on from the old function organic chemistry area.

 

Projects 

・Construction of Chirality Organized Supramolecular System Based on Self-Assembly Properties of Peptides [1]

・Molecular Aggregation System Using Preorganized Polypeptide [2]

・Bio-Inspired Catalytic Bromination System [3]

Development of Functional Molecular System Based on Self-Organization Program of Nucleobases [4]

Control of Coordination Field and Functional Properties of Conjugated Complexes [5]

etc.

Selected papers

[1] Moriuchi, T.; Hirao, T. Acc. Chem. Res. 2010, 43, 1040(http://dx.doi.org/10.1021/ar100022n).

[2] Moriuchi, T.; Yoshii, K.; Katano, C.; Hirao, T. Chem. Lett. 2010, 39, 841 (http://dx.doi.org/10.1246/cl.2010.841).

[3] Kikushima, K.; Moriuchi, T.; Hirao, T. Chem. Asian. J. 2009, 4, 1213 (http://dx.doi.org/10.1002/asia.200900142).

[4] Moriuchi, T.; Sakamoto, Y.; Noguchi, S.; Fujiwara, T.;Akine, S.; Nabeshima, T.; Hirao, T. Dalton Trans. 2012, 41, 8524 (http://dx.doi.org/10.1039/C2DT30533J).

[5] Moriuchi, T.; Hirao, T. Acc. Chem. Res. 2012, 45, 347 (http://dx.doi.org/10.1021/ar2001205).

 

Projects

・Oxidative and reductive coupling reactions [6,7]

・Redox-active organocatalyst [8]

・Redox reactions via one-electron transfer [9]

・Self-doped conductive polymers [10]

・Chemistry of bowl-shaped π-conjugated molecule "sumanene" [11]

etc.

Selected papers

[6] Oxidative cross-coupling: Amaya, T.; Maegawa, Y.; Masuda, T.; Osafune, Y.; Hirao, T. J. Am. Chem. Soc. 2015, 137, 10072 ( http://dx.doi.org/10.1021/jacs.5b05058 ) .

[7] Reductive cross-coupling: Miyasaka, A.; Amaya, T.; Hirao, T. Chem. Eur. J. 2014, 20 , 1615 (http://dx.doi.org/ 10.1002/chem.201303946 ); Amaya, T.; Kurata, Y.; Hirao, T. Org. Chem. Front. 2016, 3, 929 ( http://dx.doi.org/ 10.1039/c6qo00107f ).

[8] Amaya, T.; Suzuki, R.; Hirao, T. Chem. Commun. 2016, 52, 7790 (http://dx.doi.org/10.1039/c6cc03053j).

[9] Amaya, T.; Hata, D.; Hirao, T. Chem. Eur. J. 2015, 21 , 16427 (http://dx.doi.org/10.1002/chem.201501969 ).

[10] Amaya, T.; Abe, Y.; Inada, Y.; Hirao, T. Tetrahedron Lett. 2014, 55, 3976 (http://dx.doi.org/10.1016/j.tetlet.2014.04.115 ).

[11] Amaya, T.; Hirao, T. Chem. Rec. 2015, 15, 310 (http://dx.doi.org/10.1002/tcr.201402078).

 


 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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