１．Novel Material for Hydrogels：N-vinylamides
We have reported the novel approach to synthesize N-vinylamide monomers, and we have prepared various hydrogels using N-vinylamides. For example, N-vinylformamide (NVF) provides polycation after polymerization and hydrolysis of amide groups. N-vinylacetamide (NVA) gave an amphiphilic hydrogel. N-vinylisobutylamide (NVIBA) supplies thermosensitive polymer. Oilgel is also investigated using N-vinylamides with long alkyl chains.
Recently we introduce interpenetrating polymer network (IPN) structure in order to vary the hydrogel properties.
References and Notes
(1) M. Akashi, E. Yashima, T. Yamashita, N. Miyauchi, S. Sugita, K. Marumo,
J. Polym. Sci.: Part A: Polym.
Chem. 1990, 28, 3487.
(2) Yamamoto, K.; Serizawa, T.; Muraoka, Y.; Akashi, M. Macromolecules 2001, 34, 8014.
(3) Hiroharu Ajiro, Junji Watanabe, Mitsuru Akashi, “Diversification of Nonionic Amphiphilic
Poly(N-vinylacetamide) Hydrogels by a Double Network Approach”, Chem. Lett. 2007, 36(9), 1134-1135.
(4) This project is partially supported by Shorai Foundation for Science and Technology.
２．Materials with lower environmental load：Cyclodextrin
We found that supramolecular microstructures composed of channel-type assemblies
of γ-cyclodextrin (γ-CD) form organogels in various organic solvents and
oils. These organogels can potentially be utilized as molecular containers
and drug carriers by using the inclusion of molecules into the cavity of
γ-CD, since γ-CD is a compound of low environmental load.
(5) Toshiyuki Kida, Yasuhiro Marui, Kazuhiro Miyawaki, Eiichi Kato, Mitsuru
Akashi, “Unique Organogel
Formation with a Channel-Type Cyclodextrin assembly”, Chem. Commun.2009, 3889-3891.
(6) Yasuhiro Marui, Toshiyuki Kida, Mitsuru Akashi, “Facile Morphological Control of Cyclodextrin Nano- and
Microstructures and their Unique Organogelation Ability” Chem. Mater.,
2010, 22, 282-284.
(7) Yasuhiro Marui, Akira Kizuzawa, Toshiyuki Kida, Mitsuru Akashi, “Unique
Organogel Formation with
Macroporous Materials Constructed by the Freeze-Drying of Aqueous Cyclodextrin
Solutions” Langmuir, 2010,
Hydrogels using the high biocompatible natural polymers are prepared in
order to apply 3 dimensional scaffolds. For example, disulfide was used
as a crosslinker which is responsive to redox conditions. Electron spinning
approach is also applied to prepare various kinds of scaffolds.
(8) Michiya Matsusaki, Hiroaki Yoshida, Mitsuru Akashi, “The construction
of 3D-engineeried tissues composed
of cells and extracellular matrices by hydrogel template approach” Biomaterials
2007, 28, 2729-2737.
(9) Hiroaki Yoshida, Kristina Klinkhammer, Michiya Matsusaki, Martin Moeller, Doris Klee, Mitsuru Akashi, “
Disulfide-Crosslinked Electrospun Poly(g-glutamic acid) Nonwovens as
Macromol. Biosci. 2009, 9, 568-574.
(10) Hiroaki Yoshida, Michiya Matsusaki, Mitsuru Akashi, “Scaffold-Mediated
2D Cellular Orientations for
Construction of Three Dimensionally Engineered Tissues Composed of Oriented
Cells and Extracellular
Matrices” Adv. Funct. Mater. 2009, 19, 1001-1007. Elected as front page.
(11) Hiroaki Yoshida, Michiya Matsusaki, Mitsuru Akashi, “Development of Thick and Highly Cell-Incorporated
Engineered Tissues by Hydrogel Template Approach with Basic Fibroblast
Growth Factor or Ascorbic Acid” J.
Biomater. Sci. 2010, 21, 415-428.
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