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PROJECT


Functional Hydrogels

1.Novel Material for Hydrogels:N-vinylamides
We have reported the novel approach to synthesize N-vinylamide monomers, and we have prepared various hydrogels using N-vinylamides. For example, N-vinylformamide (NVF) provides polycation after polymerization and hydrolysis of amide groups. N-vinylacetamide (NVA) gave an amphiphilic hydrogel. N-vinylisobutylamide (NVIBA) supplies thermosensitive polymer. Oilgel is also investigated using N-vinylamides with long alkyl chains.
Recently we introduce interpenetrating polymer network (IPN) structure in order to vary the hydrogel properties.


References and Notes
(1) M. Akashi, E. Yashima, T. Yamashita, N. Miyauchi, S. Sugita, K. Marumo, J. Polym. Sci.: Part A: Polym.
  Chem. 1990, 28, 3487.
(2) Yamamoto, K.; Serizawa, T.; Muraoka, Y.; Akashi, M. Macromolecules 2001, 34, 8014.
(3) Hiroharu Ajiro, Junji Watanabe, Mitsuru Akashi, “Diversification of Nonionic Amphiphilic
  Poly(N-vinylacetamide) Hydrogels by a Double Network Approach”, Chem. Lett. 2007, 36(9), 1134-1135.
(4) This project is partially supported by Shorai Foundation for Science and Technology.


2.Materials with lower environmental load:Cyclodextrin
We found that supramolecular microstructures composed of channel-type assemblies of γ-cyclodextrin (γ-CD) form organogels in various organic solvents and oils. These organogels can potentially be utilized as molecular containers and drug carriers by using the inclusion of molecules into the cavity of γ-CD, since γ-CD is a compound of low environmental load.




References
(5) Toshiyuki Kida, Yasuhiro Marui, Kazuhiro Miyawaki, Eiichi Kato, Mitsuru Akashi, “Unique Organogel
 Formation with a Channel-Type Cyclodextrin assembly”, Chem. Commun.2009, 3889-3891.
(6) Yasuhiro Marui, Toshiyuki Kida, Mitsuru Akashi, “Facile Morphological Control of Cyclodextrin Nano- and
 Microstructures and their Unique Organogelation Ability” Chem. Mater., 2010, 22, 282-284.
(7) Yasuhiro Marui, Akira Kizuzawa, Toshiyuki Kida, Mitsuru Akashi, “Unique Organogel Formation with
 Macroporous Materials Constructed by the Freeze-Drying of Aqueous Cyclodextrin Solutions” Langmuir, 2010,
 26, 11441-11445.


3.Biomaterials:scaffold
Hydrogels using the high biocompatible natural polymers are prepared in order to apply 3 dimensional scaffolds. For example, disulfide was used as a crosslinker which is responsive to redox conditions. Electron spinning approach is also applied to prepare various kinds of scaffolds.



References
(8) Michiya Matsusaki, Hiroaki Yoshida, Mitsuru Akashi, “The construction of 3D-engineeried tissues composed
  of cells and extracellular matrices by hydrogel template approach” Biomaterials 2007, 28, 2729-2737.
(9) Hiroaki Yoshida, Kristina Klinkhammer, Michiya Matsusaki, Martin Moeller, Doris Klee, Mitsuru Akashi, “
  Disulfide-Crosslinked Electrospun Poly(g-glutamic acid) Nonwovens as Reduction-Responsive Scaffolds”
  Macromol. Biosci. 2009, 9, 568-574.
(10) Hiroaki Yoshida, Michiya Matsusaki, Mitsuru Akashi, “Scaffold-Mediated 2D Cellular Orientations for
  Construction of Three Dimensionally Engineered Tissues Composed of Oriented Cells and Extracellular
  Matrices” Adv. Funct. Mater. 2009, 19, 1001-1007. Elected as front page.
(11) Hiroaki Yoshida, Michiya Matsusaki, Mitsuru Akashi, “Development of Thick and Highly Cell-Incorporated
  Engineered Tissues by Hydrogel Template Approach with Basic Fibroblast Growth Factor or Ascorbic Acid” J.
  Biomater. Sci. 2010, 21, 415-428.




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